PNH and the GPI-Linked Proteins License:perpetual They play essential roles in

They play essential roles in the physiology of all cells

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PNH and the GPI-Linked Proteins License:perpetual They play essential roles inParoxysmal Nocturnal Hemoglobinuria (PNH) has been recognized for over a century. This mysterious disease is now understood at the level of the gene and the protein. The pathophysiology is related to a class of cell surface proteins with distinctive biochemical and physical characteristics. Recently it has been acknowledged that PNH is not rare, and once sensitive assays based on the chemistry of the proteins can be applied to many patients. Written